Radiation therapy occurs in the presence of biochemical recurrence after prostatectomy to assess whether this results in shifts of Histopathological prognostic factors such as the Gleason Score. By using ionizing radiation (such as megavoltage X-rays or radionuclides) in the treatment of cancer. The field of radiation oncology covers the integration of radiation therapy into multimodal treatment approaches. Radiation Oncology provides an open access forum for researchers and clinicians involved in the management and treatment of cancer patients, bringing together the latest research and advances in the field. Advances in treatment technology, as well as improved understanding of the underlying biological resistance mechanisms.