Cancer Cell Metabolism

Tumor cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine and fatty acids at much higher rates than their non-tumor equivalents; however, the metabolic ecology of tumors is composite because they contain multiple metabolic compartments, which are linked by the transfer of these catabolites. This metabolic changeability and flexibility enables tumor cells to generate ATP as an energy source, while maintaining the reduction–oxidation (redox) balance and committing resources to biosynthesis processes that are essential for cell survival, growth and proliferation.
  • Metabolic immuno–oncology
  • Molecular-genetic imaging
  • Preclinical and clinical studies of metabolism-related cancer therapies

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